Opioid Receptor

Receptor

Opioid Receptor

Related Products

Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Isoform Specific Products:

Opioid Receptor Isoform Comparison

Opioid Receptor Related Products (506)
Antibodies (3)
Opioid Receptor Isoform Comparison

By Effects:	Controls (8) Ligands (5) Inhibitors (22) Agonists (243) Antagonists (111) Activators (15) Modulators (17)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-165001

2,4-Difluoro U-48800 hydrochloride
2,4-Difluoro U-48800 hydrochloride is a utopioid.

HY-168815

Methylketobemidone
Methylketobemidone is structurally similar to known opioids.

HY-139390

3,4-Difluoro U-50488 hydrochloride
3,4-Difluoro U-50488 hydrochloride is a utopioid.

HY-N12180

Hodgkinsine B	Agonist
Hodgkinsine B is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine B has antiviral, antibacterial and antifungal activities.

HY-168820

2-Naphthyl U-47700
2-Naphthyl U-47700 is a utopioid.

HY-W714509

AH 8507
AH 8507 structurally belongs to the opioid compounds and is an analog of AH 7563 (HY-W714505). However, AH 8507 does not exhibit significant analgesic effects in mice in both the phenylquinone test and the hot plate test, with ED₅₀ values greater than 100 mg/kg.

HY-165021

3,4-Difluoro propyl U-47700
3,4-Difluoro propyl U-47700 is a utopioid.

HY-135032

Norcarfentanil hydrochloride
Norcarfentanil hydrochloride is an opioid and is a metabolite of Carfentanil.

HY-B0380R

Trimebutine (Standard)	Agonist
Trimebutine (Standard) is the analytical standard of Trimebutine. This product is intended for research and analytical applications. 0

HY-156988

DPI-287	Agonist
DPI-287 is a selective delta-opioid receptor (DOP) agonist with a K_i value of 0.39 nM and can be used for pain research.

HY-169867

BNTX	Antagonist
BNTX (7-Benzylidenenaltrexone) is a selective δ1-opioid receptor antagonist. BNTX antagonizes the antisecretory actions of DPDPE (HY-P1334), Deltorphin 2 (HY-P1013), and DAMGO (HY-P0210) competitively. BNTX can be used for research of antinociception.

HY-123689A

Samidorphan hydrochloride	Modulator
Samidorphan hydrochloride is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan hydrochloride acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan hydrochloride primarily acts as an opioid receptor antagonist in vivo.

HY-123689A

Samidorphan hydrochloride	Antagonist
Samidorphan hydrochloride is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan hydrochloride acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan hydrochloride primarily acts as an opioid receptor antagonist in vivo.

HY-165000

3,4-Difluoro isopropyl U-47700
3,4-Difluoro isopropyl U-47700 is a utopioid.

HY-170055

Meta-fluoro 4-ANBP
Meta-fluoro 4-ANBP (m-Fluoro 4-ANBP) is structurally similar to known opioids.

HY-B0380S2

Trimebutine-d₃ hydrochloride	Agonist
Trimebutine-d₃ hydrochloride is deuterated labeled Trimebutine (HY-B0380). Trimebutine is an opiate receptor agonist with antimuscarinic activity.

HY-17609C

Difelikefalin acetate	Agonist
Difelikefalin (CR-845; FE-202845) acetate is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin acetate produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

HY-135521

U-49900
U-49900 is a utopioid.

HY-76711S

Naltrexone-d₄	Antagonist
Naltrexone-d4 is deuterium labeled Naltrexone.

HY-119733

BU09059	Antagonist
BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA₂ of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception.

DAMGO	μ Opioid Receptor/MOR				99.90%
Matrine	μ Opioid Receptor/MOR	κ Opioid Receptor/KOR			≥98.0%
Isotodesnitazene	μ Opioid Receptor/MOR				99.78%
Sinomenine	μ Opioid Receptor/MOR				99.94%
Norbinaltorphimine dihydrochloride		κ Opioid Receptor/KOR			98.91%
Dynorphin A		κ Opioid Receptor/KOR			98.06%
Sinomenine hydrochloride	μ Opioid Receptor/MOR				99.89%
β-Endorphin, human			δ Opioid Receptor/DOR		98.09%
JTC-801				NOP Receptor/ORL1	98.91%
SNC80			δ Opioid Receptor/DOR		99.44%
BMS-986122	μ Opioid Receptor/MOR				99.94%
Endomorphin 1	μ Opioid Receptor/MOR, Ki: 1.11 nM				99.92%
Difelikefalin		κ Opioid Receptor/KOR			99.50%
Alvimopan dihydrate	μ Opioid Receptor/MOR				98.66%
Corydaline	μ Opioid Receptor/MOR				99.70%
LY2940094				NOP Receptor/ORL1	99.91%
SB-612111 hydrochloride				NOP Receptor/ORL1	99.26%
PZM21	μ Opioid Receptor/MOR				99.46%
CTAP TFA	μ Opioid Receptor/MOR, IC₅₀: 3.5 nM		δ Opioid Receptor/DOR, IC₅₀: 4500 nM		99.60%
DPDPE			δ Opioid Receptor/DOR		99.83%
Navacaprant	μ Opioid Receptor/MOR, IC₅₀: 110 nM	κ Opioid Receptor/KOR, IC₅₀: 0.8 nM	δ Opioid Receptor/DOR, IC₅₀: 6500 nM		99.97%
Dermorphin	μ Opioid Receptor/MOR				99.96%
Naldemedine tosylate	μ Opioid Receptor/MOR
BMS-986187			δ Opioid Receptor/DOR		98.93%
[Met5]-Enkephalin, amide TFA			δ Opioid Receptor/DOR		99.58%
Dynorphin A (1-8)		κ Opioid Receptor/KOR			99.88%
Porcine dynorphin A(1-13)		κ Opioid Receptor/KOR			99.85%
N-Desmethylclozapine			δ Opioid Receptor/DOR		98.99%
U-69593		κ Opioid Receptor/KOR			99.73%
Deltorphin I			δ Opioid Receptor/DOR
Morphiceptin	μ Opioid Receptor/MOR				98.29%
Endomorphin 2 TFA	μ Opioid Receptor/MOR				99.43%
BAN ORL 24				NOP Receptor/ORL1	99.68%
Dynorphin A (1-10) (TFA)		κ Opioid Receptor/KOR
DAMGO TFA	μ Opioid Receptor/MOR				99.60%
CTOP TFA	μ Opioid Receptor/MOR				99.84%
Deltorphin 2 TFA			δ Opioid Receptor/DOR		99.93%
Ro 64-6198				NOP Receptor/ORL1	99.82%
TAN-452			δ Opioid Receptor/DOR		99.44%
SNC162			δ Opioid Receptor/DOR		99.72%
ADL-5859 hydrochloride			δ Opioid Receptor/DOR		99.77%
(±)-J-113397				NOP Receptor/ORL1	98.59%
UFP-101 TFA				NOP Receptor/ORL1	99.36%
CYM51010	μ Opioid Receptor/MOR				99.12%
Sec-O-Glucosylhamaudol	μ Opioid Receptor/MOR				99.81%
GSK1521498 free base	μ Opioid Receptor/MOR				98.55%
Trimebutine	μ Opioid Receptor/MOR				99.40%
Adrenorphin	μ Opioid Receptor/MOR
J-113397	μ Opioid Receptor/MOR, Ki: 1000 ± 160 nM	κ Opioid Receptor/KOR, Ki: 640 ± 87 nM	δ Opioid Receptor/DOR, Ki: >10000 nM	NOP Receptor/ORL1, Ki: 1.8 ± 0.24 nM	99.00%
Naloxonazine dihydrochloride	μ Opioid Receptor/MOR, IC₅₀: 5.4 nM				98.1%
Dynorphin B (1-13) TFA		κ Opioid Receptor/KOR
KNT-127			δ Opioid Receptor/DOR		99.60%
ICI 199441		κ Opioid Receptor/KOR			99.39%
Endomorphin 1 acetate	μ Opioid Receptor/MOR, Ki: 1.11 nM				99.92%
SR17018	μ Opioid Receptor/MOR				98.01%
MT-7716 hydrochloride				NOP Receptor/ORL1	99.06%
AR-M 1000390 hydrochloride			δ Opioid Receptor/DOR		98.20%
[D-Ala2]leucine-enkephalin			δ Opioid Receptor/DOR		98.64%
5'-Guanidinonaltrindole hydrochloride	human μ-opioid receptor, Ki: 36.9 nM human μ-opioid receptor, pA2: 8.49				98.72%
TAN-67 dihydrobromide			δ Opioid Receptor/DOR, Ki: 0.647 nM		99.20%
LY255582	μ Opioid Receptor/MOR, Ki: 0.4 nM	κ Opioid Receptor/KOR, Ki: 2.0 nM	δ Opioid Receptor/DOR, Ki: 5.2 nM		≥98.0%
Asimadoline hydrochloride		κ Opioid Receptor/KOR			99.82%
β-Endorphin, equine TFA	μ Opioid Receptor/MOR		δ Opioid Receptor/DOR
DIPPA hydrochloride		κ Opioid Receptor/KOR			99.7%
Nociceptin (1-13), amide TFA				NOP Receptor/ORL1	99.67%
Deltorphin 2			δ Opioid Receptor/DOR
BMS-986121	μ Opioid Receptor/MOR				98.89%
Bevenopran	μ Opioid Receptor/MOR				99.82%
DPDPE TFA			δ Opioid Receptor/DOR		99.94%
Gluten Exorphin C	μ Opioid Receptor/MOR		δ Opioid Receptor/DOR		99.86%
Cebranopadol ((1α,4α)stereoisomer)				NOP Receptor/ORL1
LY2444296		κ Opioid Receptor/KOR			99.59%
Dalargin			δ Opioid Receptor/DOR		99.52%
Samidorphan-d₅	μ Opioid Receptor/MOR	κ Opioid Receptor/KOR	δ Opioid Receptor/DOR
Alvimopan monohydrate	μ Opioid Receptor/MOR				99.18%
GSK1521498 free base (hydrochloride)	μ Opioid Receptor/MOR
CTAP	μ Opioid Receptor/MOR, IC₅₀: 3.5 nM		δ Opioid Receptor/DOR, IC₅₀: 4500 nM
AT-076	μ Opioid Receptor/MOR, IC₅₀: 1.67 nM	κ Opioid Receptor/KOR, IC₅₀: 1.14 nM	δ Opioid Receptor/DOR, IC₅₀: 19.6 nM	NOP Receptor/ORL1, IC₅₀: 1.75 nM
SC13	μ Opioid Receptor/MOR
SalA-VS-07		κ Opioid Receptor/KOR
NAQ	μ Opioid Receptor/MOR, Ki: 0.55 nM	κ Opioid Receptor/KOR, Ki: 26.45 nM	δ Opioid Receptor/DOR, Ki: 132.50 nM
KOR agonist 4	human μ-opioid receptor, Ki: 280 nM	human κ-opioid receptor (hKOR), EC₅₀: 14 nM human κ-opioid receptor (hKOR), Ki: 4.8 nM	δ Opioid Receptor/DOR, Ki: 3900 nM
N-Desmethylclozapine-d₈			δ Opioid Receptor/DOR
Nociceptin (1-13), amide				NOP Receptor/ORL1
Mu opioid receptor antagonist 4	μ Opioid Receptor/MOR
SB-612111				NOP Receptor/ORL1
Bilaid C	human μ-opioid receptor, Ki: 210 nM
Dermorphin TFA	μ Opioid Receptor/MOR
DALDA	μ Opioid Receptor/MOR, Ki: 1.69 nM	κ Opioid Receptor/KOR, Ki: 4230 nM	δ Opioid Receptor/DOR, Ki: 19200 nM
KOR/DOR agonist 1	μ Opioid Receptor/MOR, Ki: 0.93 nM	κ Opioid Receptor/KOR, Ki: 0.14 nM	δ Opioid Receptor/DOR, Ki: 0.2 nM
Acetalin-3	μ Opioid Receptor/MOR
KOR agonist 3	μ Opioid Receptor/MOR, EC₅₀: 720 nM	κ Opioid Receptor/KOR, EC₅₀: 0.88 nM
DS34942424	μ Opioid Receptor/MOR
Acetyl tetrapeptide-15	μ Opioid Receptor/MOR				99.49%
Bilaid A1e	μ Opioid Receptor/MOR, Ki: 750 nM
LY2048978	μ Opioid Receptor/MOR, Ki: 0.287 nM	κ Opioid Receptor/KOR, Ki: 0.471 nM	δ Opioid Receptor/DOR, Ki: 1.05 nM
Mu opioid receptor antagonist 5	μ Opioid Receptor/MOR
(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)		κ Opioid Receptor/KOR
Mu opioid receptor antagonist 3	μ Opioid Receptor/MOR
AP-238	μ Opioid Receptor/MOR, EC₅₀: 248 nM
KOR agonist 2		κ Opioid Receptor/KOR, Ki: 1.9 nM
AT-121 hydrochloride	μ Opioid Receptor/MOR
MT-7716 free base				NOP Receptor/ORL1
Nociceptin(1-7)				NOP Receptor/ORL1
Mu opioid receptor antagonist 2	μ Opioid Receptor/MOR
Dynorphin A TFA		κ Opioid Receptor/KOR
rel-SB-612111 hydrochloride				NOP Receptor/ORL1
PIPE-3297		κ Opioid Receptor/KOR, EC₅₀: 1.1 nM
[DPen2, Pen5] Enkephalin			δ Opioid Receptor/DOR
GSK1521498	μ Opioid Receptor/MOR
Trap-101 hydrochloride				NOP Receptor/ORL1
Anrikefon		κ Opioid Receptor/KOR
β-Funaltrexamine hydrochloride	μ Opioid Receptor/MOR
ZP 120C				NOP Receptor/ORL1
3-Carboxamidonaltrexone	μ Opioid Receptor/MOR, Ki: 1.9 nM	κ Opioid Receptor/KOR, Ki: 22 nM	δ Opioid Receptor/DOR, Ki: 110 nM
KOR agonist 1	μ Opioid Receptor/MOR, EC₅₀: 701.2 nM	κ Opioid Receptor/KOR, EC₅₀: 3.4 nM	δ Opioid Receptor/DOR, EC₅₀: 1649 nM
[Met5]-Enkephalin, amide			δ Opioid Receptor/DOR
Mu opioid receptor antagonist 7	μ Opioid Receptor/MOR, IC₅₀: 29 ± 3.0 nM
DPI-3290		κ Opioid Receptor/KOR	δ Opioid Receptor/DOR
N-Benzylnaltrindole hydrochloride			δ Opioid Receptor/DOR
Dynorphin A (1-10)		κ Opioid Receptor/KOR
Akuammidine		κ Opioid Receptor/KOR
Mu opioid receptor antagonist 1	μ Opioid Receptor/MOR
K-Opioid receptor agonist-1	μ Opioid Receptor/MOR, Ki: 43 nM	κ Opioid Receptor/KOR, Ki: 0.25 nM	δ Opioid Receptor/DOR, Ki: 58 nM
Ac-RYYRWK-NH2 TFA				NOP Receptor/ORL1
μ opioid receptor agonist 3	μ Opioid Receptor/MOR, EC₅₀: 0.82 nM
BAM-12P		human κ-opioid receptor (hKOR), EC₅₀: 101 nM human κ-opioid receptor (hKOR), pEC₅₀: 6.99
Naloxegol-d₅ oxalate	μ Opioid Receptor/MOR
Nociceptin(1-7) TFA				NOP Receptor/ORL1
MOR modulator-1	μ Opioid Receptor/MOR, Ki: 0.25 nM	κ Opioid Receptor/KOR, Ki: 1.3 nM	δ Opioid Receptor/DOR, Ki: 41.1 nM
UFP-101				NOP Receptor/ORL1
Acetalin-1	μ Opioid Receptor/MOR
CTOP	μ Opioid Receptor/MOR
Axelopran	human μ-opioid receptor, pKi: 9.8	guinea pig κ-opioid receptor, pKi: 9.9	δ Opioid Receptor/DOR, pKi: 8.8
δ opioid receptor antagonist 1			δ Opioid Receptor/DOR, Ki: 1.7 nM
Opioid receptor agonist 1	μ Opioid Receptor/MOR, Ki: 5 nM	κ Opioid Receptor/KOR, Ki: 212 nM	δ Opioid Receptor/DOR, Ki: 24 nM
MOR agonist-2	μ Opioid Receptor/MOR
α-Endorphin (human)	μ Opioid Receptor/MOR
Dermorphin Analog	μ Opioid Receptor/MOR
DSLET			δ Opioid Receptor/DOR
NPFF1-R antagonist 1	μ Opioid Receptor/MOR, Ki: 3560 ± 364 nM	κ Opioid Receptor/KOR, Ki: 1390 ± 147 nM	δ Opioid Receptor/DOR, Ki: 1540 ± 132 nM
FEKAP		κ Opioid Receptor/KOR, Ki: 0.43 nM
RX809055AX	μ Opioid Receptor/MOR		δ Opioid Receptor/DOR
R-84760		κ Opioid Receptor/KOR
U-48520	μ Opioid Receptor/MOR, EC₅₀: 1561 nM
Salvinorin A propionate		κ Opioid Receptor/KOR
CHIR 4531	μ Opioid Receptor/MOR, Ki: 6 nM
Picraline	μ Opioid Receptor/MOR, Ki: 132 μM	κ Opioid Receptor/KOR, Ki: 2.38 μM	δ Opioid Receptor/DOR, Ki: 98.8 μM
BNTX			δ Opioid Receptor/DOR
Salvinorin A carbamate		κ Opioid Receptor/KOR, EC₅₀: 6.2 nM
Endomorphin 2	μ Opioid Receptor/MOR

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Opioid Receptor

Opioid Receptor

Opioid Receptor Isoform Specific Products:

Opioid Receptor Isoform Specific Products:

Opioid Receptor Related Products (506)

Antibodies (3)

Opioid Receptor Isoform Comparison

Opioid Receptor Related Products (506):